The Design and Synthesis of Bone-Active Phosphinic Acid Analogues: 1. The Pyridylaminomethane Phosphonoalkylphosphinates

Abstract

The bisphosphonic acids and their salts, the bisphosphonates, have been the subject of study by a number of research groups for their marked ability to modulate bone metabolism. From a recent study of phosphinic acid isosteres, we have designed a novel related class of bone active agents, the pyridylaminomethane phosphonoaikylphosphinates I.