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Original Articles

Synthesis and Antimicrobial Activity of Some 2(1H)-quinoxalinone-6-sulfonyl Derivatives

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Pages 1795-1807 | Received 26 Jul 2004, Accepted 07 Sep 2004, Published online: 18 Aug 2006
 

The synthesis of some quinoxalinesulfonyl derivatives is described. Two of the synthesized derivatives, 2-oxo-1,2-dihydroquinoxaline-6-sulfonyl azide (3a) and 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide (3b), were screened in vitro for their growth inhibitory activity against nine strains of Gram-positive and seven strains of Gram-negative bacteria, along with two fungal isolates. The two compounds showed broad spectrum (in vitro) activity against the bacterial strains.

Notes

*Microwave-assisted method.

*in DMSO-d6 solvent.

**in CDCl3 solvent.

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