The compounds selenolo(2,3-b)quinoline-2-carboxylic ethyl esters were synthesized in good yields by the reaction of 3-(2-chloro-3-quinolyl)acrylic ethyl esters, with the nucleophilic reagent sodium diselenide in ethanol medium under a nitrogen atmosphere. Cytogenetic studies on human blood leucocytes in vitro were evaluated for some of the synthesized compounds. Most of the synthesized compounds were tested for their antibacterial and antifungal activities.
Acknowledgments
We wish to thank Bharathiar University for the award of URF to V.N. We also thank the services rendered by the Department of Chemistry, Bharathiar University Coimbatore, IICT Hyderabad, and the Sophisticated Instrumentation Facility at IISc, Bangalore, for recording Proton NMR, IR, and Mass spectra. We convey our thanks to Dr. M. Balaji, Department of Medical Genetics, K. G. Hospital, Coimbatore, for carrying out the cytogenetic studies. We greatly acknowledge Dr. P. Lakshmana Perumalsamy and Mr. Subash kumar—Division of microbiology, Department of Environmental Sciences, Bharathiar University, Coimbatore, for the microbial studies rendered by them.
Presented as a poster presentation entitled “Synthesis of Selenolo(2,3-b)quinoline-2-carboxylic Ethyl Esters and Their Cytogenetic Studies on Human Chromosomes, Antibacterial Studies, Antifungal Studies” in the IXth International Conference on the Chemistry of Selenium and Tellurium held on 23–27th of February 2004.
Notes
*Recrystallised from petroleum ether:benzene (4:1 v/v).