Two derivatives of acetaminophen have been efficiently prepared from 4-aminophenol via a two-step procedure involving acetylation of OH and NH 2 groups and then the reaction of the acetylated compounds with diakyl acetylenedicarboxylate in the presence of triphenylphosphine. The products were obtained in good yields.
Acknowledgments
The authors express appreciation to Shahid Bahonar University of Kerman, Faculty Research Committee, for its support of this investigation.
Notes
*For two rotamers.