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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 180, 2005 - Issue 8
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Original Articles

Hydrolysis of DNA by N-Phosphoryl Branched Peptide

Anshan Xiao The Key Laboratory of Bioorganic Phosphorus and Chemical Biology, Ministry of Education, Tsinghua University, Beijing, China
,
Jie Yang The Key Laboratory of Bioorganic Phosphorus and Chemical Biology, Ministry of Education, Tsinghua University, Beijing, China
,
Yuping Feng The Key Laboratory of Bioorganic Phosphorus and Chemical Biology, Ministry of Education, Tsinghua University, Beijing, China
,
Shengli Cao Department of Chemistry, Capital Normal University, Beijing, China
&
Yufen Zhao The Key Laboratory of Bioorganic Phosphorus and Chemical Biology, Ministry of Education, Tsinghua University, Beijing, China
Pages 1947-1951 | Received 29 Jul 2004, Accepted 14 Sep 2004, Published online: 18 Aug 2006
 
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A N-phosphoryl branched peptide (DIPP-Leu) 2 -Lys-OCH 3 was found to efficiently cleave double-strand DNA such as PUC19 and Lambda DNA at pH 8.5 in 100 mM Tris-HCl buffer. The T4 ligase experiment implied that the DNA cleavage occurs via a hydrolytic path.

Acknowledgments

The authors are very grateful for the National Natural Science Foundation of China (No: 20132020) for financial support of this project.

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