Synthesis of S-triazolo[3, 4a] phthalazine and Related Polynuclear Heterocyclic Systems

The applicability and synthetic potency of the novel reagent 1-hydrazinophthalazine 1 to develop an expeditious convenient synthetic route via the annelation reactions with appropriate reagents for polyfunctionally substituted triazoles, pyrazoles, tetrazoles, and polycyclic condensed systems are reported. Chemical and spectroscopic study for the structures of the newly synthesized compounds are investigated. The prepared compounds were tested in vitro for their antimicrobial activity.

Keywords:

• 1-Hydrazinophthalazine
• annelation reactions; s-triazolo[3, 4-a] phthalazine
• tricyclic heterocycles

Acknowledgments

All strains were kindly supplied from the Botany Department, Faculty of Science, Benha University, Benha, Egypt.