Synthesis of Some New Thiazole, Thiophene, and 2,3-Dihydro-1,3,4-thiadiazole and Pyrimidino[1,2-b]indazole Derivatives

Hydrazonoyl halides 4a – g reacted with methyl carbodithioate 3 thioanilide 10 to give 1,3,4-thiadiazoles { 5a–g and 13a–g ,} respectively. Thioanilide 10 reacted with ω-bromoacetophenones 14a – e to give the acyclic product 15a – e , which was converted to the thiophenes 16a–e and to the thiazoles 17a–e , respectively. Structures of the newly synthesized compounds were elucidated on the basis of elemental analysis, spectral data, and alternative synthesis route whenever possible.

Keywords:

• Dimidone
• hydrazonoyl halides
• thiophene
• thiazoles
• thiadiazoles