A Mild and Chemoselective Catalyst for Thioacetalization Under Solvent Free Conditions

Protection of a variety of carbonyl compounds as dithioacetals using P ₂ O ₅ /SiO ₂ (75%), as a mild and chemoselective catalyst, was achieved under solvent free conditions in very good yields.

Keywords:

• 1,3-dithiolane
• dithioacetalization
• diphosphorus pentoxide

Acknowledgments

We gratefully acknowledge the funding support received for this project from the Isfahan University of Technology (IUT), IR Iran (Abdol R. Hajipour), and Grant GM 33138 (Arnold E. Ruoho) from the National Institutes of Health. Further financial support from Center of Excellency in Chemistry Research (IUT) is gratefully acknowledged.

Notes

^a Reaction was carried out at r.t. in CH₂Cl₂.

^b Reaction was carried out at r.t. in CH₂Cl₂/MeOH.

^c Reaction was carried out at r.t. in CH₂Cl₂.

^d Reaction was carried out at r.t. in CH₂Cl₂.

^e Reaction was carried out at r.t. in CH₃CN.

^f Reaction was carried out at 20°C in benzene.

^g Reaction was carried out at r.t. in diethylether.