Protection of a variety of carbonyl compounds as dithioacetals using P 2 O 5 /SiO 2 (75%), as a mild and chemoselective catalyst, was achieved under solvent free conditions in very good yields.
Acknowledgments
We gratefully acknowledge the funding support received for this project from the Isfahan University of Technology (IUT), IR Iran (Abdol R. Hajipour), and Grant GM 33138 (Arnold E. Ruoho) from the National Institutes of Health. Further financial support from Center of Excellency in Chemistry Research (IUT) is gratefully acknowledged.
Notes
a Reaction was carried out at r.t. in CH2Cl2.
b Reaction was carried out at r.t. in CH2Cl2/MeOH.
c Reaction was carried out at r.t. in CH2Cl2.
d Reaction was carried out at r.t. in CH2Cl2.
e Reaction was carried out at r.t. in CH3CN.
f Reaction was carried out at 20°C in benzene.
g Reaction was carried out at r.t. in diethylether.