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Original Articles

BIOLOGICAL ACTIVITY OF AMINOPHOSPHONIC ACIDS

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Pages 193-215 | Received 16 Jul 1990, Accepted 28 Apr 1991, Published online: 23 Sep 2006
 

Abstract

Aminophosphonates are analogues of amino acids in which a carboxylic moiety is replaced by phosphonic acid or related groups. Acting as antagonists of amino acids, they inhibit enzymes involved in amino acid metabolism and thus affect the physiological activity of the cell. These effects may be exerted as antibacterial, plant growth regulatory or neuromodulatory. Chosen representative examples of biologically active aminophosphonates are presented in some detail.

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