STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 78. NEW ASPECTS ON THE INDUCED ASYMMETRIC ADDITION OF DIALKYL PHOSPHITE TO ALDIMINES—AN EFFECTIVE SYNTHESIS OF CHIRAL 1-ARYLPHOSPHONOGLYCINE DERIVATIVES

Chengye Yuan Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Lu, Shanghai, 200032, China

Shusen Li Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Lu, Shanghai, 200032, China

Guoquan Wang Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Lu, Shanghai, 200032, China

Yilin Ma Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Lu, Shanghai, 200032, China

Abstract

Addition of dialkyl phosphites to Schiff bases derived from (R)-2-methoxy-1-phenylethylamine or (R)-phenylglycine methyl ester afforded (1R, 1′R)-1-arylphosphonoglycine derivatives with moderate to high diastereoselectivity. The influence of catalysts and solvents and the structural effects of the substrates on this stereochemical process were reported.

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STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 78. NEW ASPECTS ON THE INDUCED ASYMMETRIC ADDITION OF DIALKYL PHOSPHITE TO ALDIMINES—AN EFFECTIVE SYNTHESIS OF CHIRAL 1-ARYLPHOSPHONOGLYCINE DERIVATIVES

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STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 78. NEW ASPECTS ON THE INDUCED ASYMMETRIC ADDITION OF DIALKYL PHOSPHITE TO ALDIMINES—AN EFFECTIVE SYNTHESIS OF CHIRAL 1-ARYLPHOSPHONOGLYCINE DERIVATIVES

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