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Abstract
Piperidine catalysed reaction of methyl phenylphosphinylacetic acid 1 with paraformaldehyde and primary or secondary alcohols gave methyl phenyl(1-alkoxymethyl)vinylphosphinates 3a-f. Conjugate addition of primary amines or ammonia to 3 followed by hydrolysis of the resulting 2-aminophosphinates 5 and 7 afforded 2-aminoethylphenylphosphinic acids 6 and 8 respectively.