SYNTHESIS OF NEW SPIRO HETEROCYCLIC COMPOUNDS DERIVED FROM RHODANINE DERIVATIVES

Abstract

5,5-Dibronio-3-phenyl-2-thioxo-4-thiazolidinone 2, was reacted with bidentates, or with CS₂ and active methylenes under FTC conditions to afford the corresponding spiro compounds 4a-h or 5a-e. 5-ethoxymethylene-3-phenyl-2-thioxo-4-thiazolidinone 3 was treated with diamino or aminomercapto compounds to give the desired products 6a-d. Treatment of compound 3 with malononitrile gave compound 7. Reaction of compound 7 with some active methylenes affords the corresponding spiro cyclopentenes 8a-c.

Key Words:

• dibromo-4-thiazolidinone derivatives
• 5-ethoxymethylene-4-thiazolidinone derivatives
• dithietane
• spiropentene