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Abstract
A series of 0,0-diethyl-α-(p-toluenesulphonureado) phosphonates have been synthesized by the Mannich-type reaction of p-toluenesulphonurea, (substituted) benzaldehydes and dialkyl phosphites with acetyl chloride as the solvent. The bioassay results showed that some of them possess good anti-TMV (Tobacco Mosaic Virus) activities and the quantitative structure-anti-TMV activity relationship (QSAR) has also been studied.