ENZYMES IN ORGANIC CHEMISTRY, 8.^[11 PROTEASE-CATALYZED KINETIC RESOLUTION OF α-CHLOROACETOXYPHOSPHONATES IN A BIPHASIC SYSTEM

Friedrich Hammerschmidt Institut für Organische Chemie der Universität Wien, Währingerstraβe 38, A-1090, Wien, Austria

Frank Wuggenig Institut für Organische Chemie der Universität Wien, Währingerstraβe 38, A-1090, Wien, Austria

Abstract

Protease Chirazyme® P-2 hydrolyses racemic α-chloroacetoxyphosphonates (±1 enantiose-lectively to furnish α-hydroxyphosphonates (R)-(-)-2 with ee's ranging from 31 to 97% at a conversion of 45% and unreacted esters (S)-(+)-1.

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ENZYMES IN ORGANIC CHEMISTRY, 8.^[11 PROTEASE-CATALYZED KINETIC RESOLUTION OF α-CHLOROACETOXYPHOSPHONATES IN A BIPHASIC SYSTEM

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ENZYMES IN ORGANIC CHEMISTRY, 8.[11 PROTEASE-CATALYZED KINETIC RESOLUTION OF α-CHLOROACETOXYPHOSPHONATES IN A BIPHASIC SYSTEM

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ENZYMES IN ORGANIC CHEMISTRY, 8.^[11 PROTEASE-CATALYZED KINETIC RESOLUTION OF α-CHLOROACETOXYPHOSPHONATES IN A BIPHASIC SYSTEM