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Original Articles

A NEW EFFICIENT SYNTHESIS OF ω-AMINOALKYLIDENE-1,1-BISPHOSPHONATE TETRAETHYLESTERS

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Pages 219-229 | Received 21 Jan 1997, Accepted 11 Feb 1997, Published online: 24 Sep 2006
 

Abstract

Bisphosphonates are interesting therapeutic agents in the management of bone diseases and since several years our laboratory has been developing the chemistry of 1,1-bisphosphonates. This paper describes an original synthesis of two aminoalkylidenebisphosphonates by first preparing the intermediate hydroxyalkylidenebisphosphonates which are transformed into amines via the azides.

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