Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application

Abstract

Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5 mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.

Keywords:

• Antibacterial activity
• Biomedical applications
• Complexation
• Hydrogel
• Itaconic acid
• Silver(I) ion
• 2-Hydroxyethyl methacrylate

ACKNOWLEDGMENTS

This work has been supported by the Ministry of Science and Technological Development of the Republic of Serbia (Grant Nos. 145072 and 141013).