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Abstract
In pharmaceutical science, construction of drug delivery system based on various carriers is a great challenge. Here we proposed a new silica carrier for drug delivery. The carrier is characterized by penetrable macropores and large pore volume, which renders it an ideal carrier for drug loading especially for macromolecular drugs. Bovine serum albumin (BSA) and oxaprozin were used as models to investigate its delivery behavior. From the results, it demonstrates that the drug loading capacity is very high (for BSA, it reaches 212.2 wt% [drug/carrier]). It is also found that an ultra-fast release for oxaprozin was achieved on this carrier, indicating the material is suitable for constructing enhanced delivery platform for specific drugs to improve the bioavailability.