Cytogenetic remission with imatinib therapy in hypereosinophilic syndrome with trisomy 8 and resolution of severe cardiac dysfunction

Abstract

We report a 50-year-old patient with idiopathic hypereosinophilic syndrome with trisomy 8 who experienced a complete and durable hematological and cytogenetic remission with low-dose imatinib therapy. He also had a significant reversal of cardiac dysfunction with a reduction in cardiac hypertrophy, resolution of pericardial effusion and mitral and tricuspid regurgitation. He remained in remission 3 years after therapy.

Keywords:

• Cytogenetics
• hypereosinophilic syndrome
• imatinib
• tyrosine kinase
• FIP1-like-1-platelet-derived growth factor alpha (FIP1L1-PDGFRA)
• remission