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Leukemia & Lymphoma Volume 48, 2007 - Issue 4
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Original

Comparison of 18F Flurodeoxyglucose PET with Ga-67 scintigraphy and conventional imaging modalities in pediatric lymphoma

Rajen J. Mody Department of Pediatrics and Communicable Diseases
,
Chuong Bui Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA
,
Raymond J. Hutchinson Department of Pediatrics and Communicable Diseases
,
Kirk A. Frey Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA
&
Barry L. Shulkin Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, USACorrespondence[email protected]
Pages 699-707 | Received 05 May 2006, Accepted 17 Dec 2006, Published online: 01 Jul 2009
 
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Abstract

Flurodeoxyglucose PET (FDG PET) is very useful for staging and restaging adult lymphomas. Its effectiveness in childhood lymphomas is less established. To evaluate the potential utility of FDG PET in the care of pediatric patients with lymphomas, we examined the clinical data and imaging findings of 26 patients, 8 – 19 years of age (14 HD, 12 NHL) who underwent 55 FDG PET studies. Results were compared with CT/MRI and gallium scans. FDG PET provided incremental, clinically important information in 21% of HD cases and 33% of NHL cases. It was especially useful in distinguishing scar tissue from residual disease at the end of therapy. In both HD and NHL, FDG PET had higher sensitivity (94%, 90%) and specificity (100%, 88%) than CT/MRI and gallium scanning. These results indicate that FDG PET is useful in the management of pediatric lymphomas.

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