Eosinophil-rich tissue infiltrates in chronic myelomonocytic leukemia patients

Abstract

Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder that associates dysplastic and proliferative features. Tissue inflammatory disorders occur in a fraction of CMML patients during the course of their disease. Here, we describe the occurrence of eosinophil-rich tissue inflammation, including eosinophilic pneumonia, chondritis, and cystitis, in CMML patients. Whole exome sequencing of leukemic cells did not identify a recurrent genetic abnormality among these three patients who were clinically improved by local or oral corticosteroids. Hypomethylating drugs were subsequently added in two of them, allowing decreasing corticosteroid doses and further treating their hematopoietic malignancy.

Keywords:

• Chronic myelomonocytic leukemia
• eosinophils
• inflammatory tissue

Acknowledgements

Dr. Nolwenn Lucas received a grant from the Ligue Nationale Contre le Cancer. Pr Olivier Lambotte performed consultancy for BMS, MSD, and Genzyme for activities outside the current work.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org.10.1080/10428194.2017.1330468.

Additional information

Funding

Dr. Nolwenn Lucas received a grant from the Ligue Nationale Contre le Cancer.