Abstract
Acute Myeloid Leukemia (AML) is a hematopoietic progenitor/stem cell disorder in which neoplastic myeloblasts are stopped at an immature stage of differentiation and lost the normal ability of proliferation and apoptosis. MicroRNAs (miRNAs) are small noncoding, single-stranded RNA molecules that can mediate the expression of target genes. While miRNAs mean to contribute the developments of normal functions, abnormal expression of miRNAs and regulations on their corresponding targets have often been found in the developments of AML and described in recent years. In leukemia, miRNAs may function as regulatory molecules, acting as oncogenes or tumor suppressors. Overexpression of miRNAs can down-regulate tumor suppressors or other genes involved in cell differentiation, thereby contributing to AML formation. Similarly, miRNAs can down-regulate different proteins with oncogenic activity as tumor suppressors. We herein review the current data on miRNAs, specifically their targets and their biological function based on apoptosis in the development of AML.
Potential conflict of interest
Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2018.1480769.
Additional information
Funding
Notes on contributors
Chengcheng He
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.
Bo Luo
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.
Nan Jiang
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.
Yu Liang
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.
Yancheng He
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.
Jingyuan Zeng
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.
Jiajia Liu
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.
Xiaoli Zheng
Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.