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Leukemia & Lymphoma Volume 60, 2019 - Issue 2
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Original Article: Clinical

Hodgkin lymphoma of the elderly patients: a retrospective multicenter analysis from the Polish Lymphoma Research GroupFootnote*

Tomasz Wróbela Department of Hematology, Wroclaw Medical University, Wrocław, Poland;
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Przemysław Biecekb Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland; ORCID Iconhttps://orcid.org/0000-0001-8423-1823
ORCID Icon,
Justyna Rybkaa Department of Hematology, Wroclaw Medical University, Wrocław, Poland;
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Anna Szulgoc Department of Oncology, Center of Oncology of Professor Franciszek Łukaszczyk, Bydgoszcz, Poland;
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Natalia Sorbottenc Department of Oncology, Center of Oncology of Professor Franciszek Łukaszczyk, Bydgoszcz, Poland;
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Agnieszka Gizad Department of Hematology, Collegium Medicum of the Jagiellonian University, Kraków, Poland;
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Agata Tyczyńskae Department of Oncology and Radiotherapy, Gdynia Oncology Center, Gdynia, Poland;
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Elżbieta Nowaraf Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland;
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Agnieszka Badora-Rybickaf Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland;
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Krzysztof Adamowiczg Regional Oncology Centre in Gdansk, Gdańsk, Poland;
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Waldemar Kulikowskih Department of Hematology, University of Warmia and Mazury, Olsztyn, Poland;
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Renata Kroll-Balcerzaki Department of Hematology, University of Medical Sciences, Poznan, Poland;
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Andrzej Balcerzaki Department of Hematology, University of Medical Sciences, Poznan, Poland;
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Wojciech Spychałowiczj Internal Medicine and Oncology Clinic, Silesian Medical University, Katowice, Poland;
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Ewa Kalinka-Warzochak Department of Chemotherapy, Regional Cancer Center, Lodz, Poland;
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Beata Kumiegal Department of Hematology, Brzozow Oncology Center, Brzozów, Poland;
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Joanna Drozd-Sokołowskam Department of Haematology, Oncology and Internal Medicine, The Medical University of Warsaw, Warsaw, Poland;
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Edyta Suboczn Department of Haematology, Military Institute of Medicine in Warsaw, Warsaw, Poland;
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Agata Sałeko Department of Hematology KSW No.1 and Medical Faculty, University of Rzeszow, Rzeszow, Poland;
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Maciej Machaczkao Department of Hematology KSW No.1 and Medical Faculty, University of Rzeszow, Rzeszow, Poland;
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Jadwiga Hołojdap Department of Hematology, Provincial Specialist Hospital, Legnica, Poland;
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Joanna Pogrzebaq Department of Hematology, Provincial Specialist Hospital, Opole, Poland;
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Olga Dobrzyńskaa Department of Hematology, Wroclaw Medical University, Wrocław, Poland;
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Ewa Chmielowskac Department of Oncology, Center of Oncology of Professor Franciszek Łukaszczyk, Bydgoszcz, Poland;
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Wojciech Jurczakd Department of Hematology, Collegium Medicum of the Jagiellonian University, Kraków, Poland;
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Wanda Knopińska-Posłusznyh Department of Hematology, University of Warmia and Mazury, Olsztyn, Poland;
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Krzysztof Leśniewski-Kmake Department of Oncology and Radiotherapy, Gdynia Oncology Center, Gdynia, Poland; ;r Department of Oncological Propaedeutics, Medical University of Gdańsk, Gdańsk, Poland;
&
Jan Maciej Zauchae Department of Oncology and Radiotherapy, Gdynia Oncology Center, Gdynia, Poland; ;s Department of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, PolandCorrespondence[email protected]
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Pages 341-348 | Received 28 Nov 2017, Accepted 20 May 2018, Published online: 06 Jul 2018
 
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Abstract

We retrospectively analyzed long-term disease outcome of 350 elderly Hodgkin Lymphoma (eHL) patients treated with ABVD/ABVD-like regimen enrolled in the PLRG-R9 study between 2001 and 2013 in Poland. Complete remission was reported for 73% of early (ES) and 61% advanced stage (AS) patients. Nine (10%) ES and 56 (20%) AS patients have died. With the median follow-up of 36 (1–190) months, 3-year EFS and OS was 0.74 (95%CI: 0.63–0.85) and 0.90 (95%CI: 0.82–0.98) for ES; 0.51 (95%CI: 0.44–0.57), and 0.81 (95%CI: 0.75–0.86) for AS patients, respectively. For ES patients, Cox regression revealed ECOG <2 and age >70 as predictive for inferior OS and EFS. For AS patients, the most predictive for OS was the presence of cardiovascular disorders (CVD) (p = .00044), while for EFS four factors were significantly associated with a poor outcome: ECOG< 2, age >70 years, CVD and extranodal disease. In conclusion, CVD significantly impacts outcomes of ABVD-treated advanced eHL patients.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2018.1482539.

Notes

* Preliminary data from this study have been presented at the 52nd conference of the American Society of Hematology in San Francisco, December 2014.

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