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Leukemia & Lymphoma Volume 60, 2019 - Issue 3
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Original Article

Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Piero FarruggiaPediatric Hematology and Oncology Unit Oncology Department, A.R.N.A.S. Ospedali Civico Di Cristina e Benfratelli, Palermo, Italy; Correspondence[email protected]
,
Giuseppe PuccioDepartment of Sciences for Health Promotion and Mother and Child Care, University of Palermo, Palermo, Italy;
,
Francesco LocatelliDipartimento di Oncoematologia Pediatrica, IRCCS Ospedale Bambino Gesù, Roma, University of Pavia, Italy;
,
Mariarita VetroDepartment of Sciences for Health Promotion and Mother and Child Care, University of Palermo, Palermo, Italy;
,
Marta PillonDipartimento di Oncoematologia Pediatrica, Università di Padova, Padova, Italy;
,
Angela TrizzinoPediatric Hematology and Oncology Unit Oncology Department, A.R.N.A.S. Ospedali Civico Di Cristina e Benfratelli, Palermo, Italy;
,
Alessandra SalaClinica Pediatrica, Universita’ Milano – Bicocca A.O. San Gerardo – Fondazione MBBM, Monza, Italy;
,
Salvatore BuffardiDipartimento di Oncologia Pediatrica A.O. Santobono-Pausilipon, Napoli, Italy;
,
Alberto GaraventaDipartimento di Ematologia e Oncologia Pediatrica, Istituto G. Gaslini, Genova, Italy;
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Francesca RossiDipartimento di Pediatria II Ateneo di Napoli, Servizio di Oncologia Pediatrica, Napoli, Italy;
,
Maurizio BianchiS.C. Oncoematologia Pediatria e Centro Trapianti, Ospedale Infantile Regina Margherita, Torino, Italy;
,
Marco ZeccaOncoematologia Pediatrica, Fondazione IRCCS, Policlinico San Matteo, Pavia, Italy;
,
Andrea PessionDipartimento di Oncoematologia Pediatrica, ‘Lalla Seragnoli’ Clinica Pediatrica Policlinico Sant’Orsola Malpighi, Bologna, Italy;
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Claudio FavreOncologia Clinica Pediatrica e Trapianto Midollo Osseo, Azienda Ospedaliera – Università, Pisa, Italy;
,
Salvatore D’AmicoClinica Pediatrica, Oncologia Pediatrica, Catania, Italy;
,
Massimo ProvenziSezione Oncoematologia Pediatrica, Dipartimento di Pediatria, Ospedali Riuniti di Bergamo, Bergamo, Italy;
,
Giulio Andrea ZanazzoU.O. Emato-Oncologia Pediatrica, Università degli Studi di Trieste Osp.le Infantile Burlo Garofolo, Trieste, Italy;
,
Antonella SauU.O. Oncoematologia Pediatrica, Ospedale Civile Spirito Santo, Pescara, Italy;
,
Nicola SantoroUnità Operativa Complessa di Oncologia ed Ematologia Oncologica Pediatrica-Policlinico, Bari, Italy;
,
Rosamaria MuraOncoematologia Pediatrica e Patologia della coagulazione, Ospedale Regionale per le Microcitemie, Cagliari, Italy;
,
Caterina EliaS.S. Radioterapia Pediatrica e Area Giovani, IRCCS Centro di Riferimento Oncologico Aviano, Pordenone, Italy;
,
Tommaso CasiniDipartimento di Oncoematologia Pediatrica A.O.U Meyer, Firenze, Italy;
,
Maurizio MascarinS.S. Radioterapia Pediatrica e Area Giovani, IRCCS Centro di Riferimento Oncologico Aviano, Pordenone, Italy;
&
Roberta BurnelliOncoematologia Pediatrica, Azienda Ospedaliera Universitaria Ospedale Sant’Anna, Ferrara, Italy
 show all
Pages 696-702 | Received 13 Apr 2018, Accepted 15 Jun 2018, Published online: 10 Oct 2018
 
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Abstract

Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

Acknowledgements

The authors thank The Parents’ Association A.S.L.T.I – Liberi di crescere for supporting the activity of the Pediatric Onco-Hematology Unit of Civico Hospital, Palermo. The preliminary results of this study have been submitted at 24th EHA Congress (Stockholm, Sweden, 14–17 June 2018).

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2018.1493732.

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