Advanced search
Publication Cover
Leukemia & Lymphoma Volume 60, 2019 - Issue 5
Submit an article Journal homepage
133
Views
2
CrossRef citations to date
0
Altmetric
Original Article

BIM deletion polymorphism accounts for lack of favorable outcome in Japanese females with follicular lymphoma

Yoshikazu ItoDepartment of Hematology, Tokyo Medical University, Tokyo, Japan; Correspondence[email protected]
,
Tomohiro UmezuInstitute of Medical Science, Tokyo Medical University, Shinjuku-ku, Japan;
,
Kenichi TadokoroDevelopment of Clinical Genomics, BML, Inc, Saitama, Japan;
,
Yuu SaitoDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Seiichiro KatagiriDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Tamiko SuguroDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Michiyo AsanoDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Seiichiro YoshizawaDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Daigo AkahaneDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Yuko TanakaDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Hiroaki FujimotoDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Seiichi OkabeDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Moritaka GotohDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Tetsuzo TauchiDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
,
Chiaki KawanaInstitute of Medical Science, Tokyo Medical University, Shinjuku-ku, Japan;
,
Junko H. OhyashikiInstitute of Medical Science, Tokyo Medical University, Shinjuku-ku, Japan;
,
Naoya NakamuraDepartment of Pathology, Tokai University School of Medicine, Kanagawa, Japan
&
Kazuma OhyashikiDepartment of Hematology, Tokyo Medical University, Tokyo, Japan;
show all
Pages 1283-1288 | Received 05 Jun 2018, Accepted 21 Sep 2018, Published online: 27 Nov 2018
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Deletion polymorphism of BCL-2-like protein 11 (BIM) is specifically found in East Asia. To explain some epidemiological discrepancies between Asian and Western countries, we analyzed a silent single nucleotide polymorphism (SNP) in exon 5 (c465C > T) and a deletion site (2903 bp) in intron 2 in 77 patients with follicular lymphoma by the Q-invader method using PCR. In females, 5-year progression-free survivals (PFS) were 20.0% in the BIM deletion group, 66.7% in the SNP group and 81.5% in the wild-type (WT) group (p = .0012). In the WT group, 5-year PFS was 40.4% in males (p = .0448 vs. female PFS). This tendency was strengthened in patients receiving rituximab (26.9% vs. 84.2%, p = .006). Superior PFS in the WT females in Japan was comparable with the results of cohort studies in the United States and Sweden. Favorable prognosis in Japanese females may be masked by the BIM deletion polymorphism.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2018.1529310.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,065.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.