Lymphoma survivors have an increased long-term risk of chronic kidney disease

Abstract

With improving lymphoma survival, late effects of therapy have emerged. Here, we describe pattern of long-term chronic kidney disease (CKD) in lymphoma survivors. Demographics, comorbidities, lymphoma histology, treatment, and outcome were recorded. Glomerular filtration rate (GFR) was recorded at diagnosis, 1, 2, 5, and 10 years. Rate of GFR decline with time and CKD-free survival were recorded. In 397 patients, median age was 55.3 (18–88), 54% were male, 60% were African Americans, 42% had hypertension (HTN), 15% had DM, 13% had hyperuricemia, 86% received chemotherapy, and 14% had baseline CKD. Total 125 (31%) patients developed CKD in 10 years after lymphoma diagnosis. Probability of CKD development increased significantly with time (23% at 1 year to 41% at 10 years). Rate of GFR decline was 4.6 mL/min/per year. Age, HTN, hyperuricemia, and DM (in young patients) predicted risk of CKD. Thus, lymphoma survivors are at substantial long-term risk of CKD development.

Keywords:

• Lymphoma
• chronic kidney disease
• survivorship

Author contributions

SHD contributed to conceptualization, data collection, data analysis and manuscript writing, GA contributed to data collection, SD conducted statistical analysis, JV contributed to conception, data analysis and manuscript writing, VM contributed to conception of the study, data analysis and manuscript writing.

Disclosure statement

The authors report no conflict of interest.