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Leukemia & Lymphoma Volume 62, 2021 - Issue 1
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Original Articles

Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia – a distinct subtype with favorable prognosis

Musa Yilmaza Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Hagop M. Kantarjiana Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Gokce Torunerb Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
C. Cameron Yinb Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Rashmi Kanagal-Shamannab Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0001-7829-5249
ORCID Icon,
Jorge E. Cortesc Georgia Cancer Center, Augusta University, Augusta, GA, USAORCID Iconhttps://orcid.org/0000-0002-8636-1071
ORCID Icon,
Ghayyas Issaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Nicholas J. Shorta Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Joseph D. Khouryb Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Guillermo Garcia-Maneroa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Farhad Ravandia Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Tapan Kadiaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Marina Konoplevaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
William G. Wierdaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Nitin Jaina Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Zeev Estrova Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-1623-3613
ORCID Icon,
Koji Sasakia Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Sherry Piercea Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Susan M. O'Briend Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA, USA
&
Elias J. Jabboura Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence[email protected]
 show all
Pages 224-228 | Received 20 Apr 2020, Accepted 08 Sep 2020, Published online: 21 Sep 2020
 
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Abstract

The recurring translocation t(1;19) (q23;p13) with TCF3-PBX1 rearrangements are uncommon in adult acute lymphoblastic leukemia (ALL), and their prognostic impact remains to be described in the era of modern chemotherapies. We investigated 427 adult patients with newly diagnosed pre-B ALL, 16 (4%) had t(1;19)(q23;p13) at diagnosis. All 16 patients achieved complete remission after induction with intensive chemotherapy, and with a median of 7-year follow-up, 2 relapsed. The 5-year cumulative incidence of relapse and overall survival rates were 14% and 82%, respectively. Our analysis showed that adult patients with t(1;19)(q23;p13) positive ALL had favorable prognosis with intensive chemotherapy regimens.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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