Comparison of prognostic scores in transplant-ineligible patients with peripheral T-cell lymphoma not otherwise specified and angioimmunoblastic T-cell lymphoma: a retrospective study from the national hospital organization in Japan

Abstract

We retrospectively analyzed the risk factors for outcomes among patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS, n = 100) and angioimmunoblastic T-cell lymphoma (AITL, n = 128) who did not receive hematopoietic stem cell transplantation between 2008 and 2018. We designed a comparison of prognostic scores specifically for PTCL-NOS and AITL. The international prognostic index (IPI) was useful for investigating the risk factors associated with outcomes among transplant-ineligible patients with PTCL-NOS (Harrell’s c-statistic 0.715) and AITL (c-statistic 0.615). The prognostic index for T-cell lymphoma (PIT), modified PIT, and the International Peripheral T Cell Lymphoma Project for overall survival (OS) seemed to identify separate prognostic groups, based on visual assessment of Kaplan–Meier curves. However, better c-statistics (>0.7) were only found for the IPI score for OS in PTCL-NOS. Strategies that carefully select PTCL patients with higher IPI scores may help to identify individuals suitable for novel therapies.

Keywords:

• Peripheral T-cell lymphoma not otherwise specified
• angioimmunoblastic T-cell lymphoma
• transplant-ineligible
• international prognostic index

Acknowledgments

We thank the patients and clinical staff for their participation in the study. We also thank the doctors in the 12 hospitals for checking the medical records. The authors also acknowledge the Clinical Research Institute, Kyushu Medical Hospital for editorial support. The article processing charges were funded by the authors. We thank Susan Furness, PhD, and Gillian Campbell, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.

Disclosure statement

The authors declare that there are no competing financial or non-financial interests regarding this article.

Ethics approval

This was a retrospective study with no experimental interventions. The study was approved by the Institutional Review Board of our 12 institutions in the National Hospital Organization group in Japan.

Author contributions

S. Yamasaki designed the study, analyzed the data, and prepared the manuscript. S. Yamasaki, H. Iida., I.Y., T.K., M.S., M.M, N.S., T.K., K.S., S.S., H.T., S. Yoshida., M.O., T.K., T.O., Y.S., K.O., H.N., and H. Iwasaki prepared and reviewed the manuscript. All named authors met the International Committee of Medical Journal Editors criteria for authorship of this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Additional information

Funding

The article processing charges were funded by the authors.