Hyperpigmented mycosis fungoides: a retrospective and comparative analysis with other subtypes of mycosis fungoides

Abstract

In this study, the clinicopathologic features and survival outcomes of patients with hyperpigmented MF from a single tertiary referral center database were retrospectively evaluated. Hyperpigmented MF accounted for 10.9% (14/128) of all MF cases. The mean age at diagnosis was 46.9 years, and the female-to-male ratio was 1:1.3. Concurrent hypopigmented, ichthyosiform, and poikilodermatous lesions were detected in 21.4%, 14.3%, and 14.3% of the patients, respectively. Histopathologically, most patients (85.7%) showed interface change with pigment incontinence. Double negative (CD4- and CD8-) immunophenotypes were more frequent in patients with hyperpigmented MF (25%) than in those with other MF subtypes (9.8%). Most patients (85.7%) had early-stage disease at diagnosis. The survival outcomes did not differ significantly between hyperpigmented and other MF subtypes. In conclusion, hyperpigmented MF often accompanies other atypical MF variants and is frequently associated with atypical immunophenotypes. The outcomes of hyperpigmented MF are comparable to those of other MF subtypes.

Keywords:

• Mycosis fungoides
• cutaneous T-cell lymphoma
• hyperpigmented
• pigmented

Disclosure of interest

The authors report no conflict of interest.

Neither this manuscript nor one with substantially similar content under our authorship has been presented or published.

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request

IRB approval status

This study was approved by the relevant institutional review board.

Additional information

Funding

This study was supported by a grant, the ‘Elimination of Cancer Project Fund’, from the Asan Cancer Institute of Asan Medical Center, Seoul, Korea.