The regulatory mechanism of amino acids on milk protein and fat synthesis in mammary epithelial cells: a mini review

Abstract

Mammary epithelial cell (MEC) is the basic unit of the mammary gland that synthesizes milk components including milk protein and milk fat. MECs can sense to extracellular stimuli including nutrients such as amino acids though different sensors and signaling pathways. Here, we review recent advances in the regulatory mechanism of amino acids on milk protein and fat synthesis in MECs. We also highlight how these mechanisms reflect the amino acid requirements of MECs and discuss the current and future prospects for amino acid regulation in milk production.

Keywords:

• Amino acid
• mammary epithelial cells
• milk fat
• milk protein
• mTOR
• SREBP-1c

Author Contributions

Meihong Han: Wrote paper. Minghui Zhang: Wrote, revised, and submission.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by grants from National Natural Science Foundation of China [No. 31700683].