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Abstract
The radioprotective effects of Hippophae rhamnoides (common name, sea buckthorn) leaf extract, designated SBL-1, were investigated in Swiss Albino strain ‘A’ mice. Against 100% mortality in whole-body irradiated (60Co-gamma-rays, 10 Gy) controls, a single dose of the SBL-1 rendered >90% survivors when administered 30 min before irradiation and 90% to 80% survivors when administered 1 to 4 h before irradiation. SBL-1 activated proliferation of hemopoietic stem cells countered a radiation-induced decrease in total thiols and an increase in free radicals in plasma and liver; inhibited lipid peroxidation, and normalized the liver alkaline phosphatase activity. This study demonstrated high radioprotective potential of H. rhamnoides leaves.
The authors acknowledge research facilities extended by directors of the INMAS and DIPAS; the efforts of Drs. O. P. Chaurasia, S. K. Dwivedi, F. R. L Leh, in procurement of plant material; and of Drs. Praveen Vats and Yogendra Kumar, DIPAS, Delhi, for HPLC studies.