Antiviral Activity of Cardiospermum Halicacabum L. Extract against Coinfecting Agents HIV and HBV

Abstract

Current inadequate and inefficient market drugs used for the control and management of human immunodeficiency virus (HIV) coinfection with hepatitis viruses (HBV) poses serious threats to public health. The medicinal plant Cardiospermum halicacabum, having known anticancer and immunostimulatory activity was explored for their control in this study. The plant active principles extracted using five solvents were identified, and tested for antiHIV, antiHBV and phytochemical constituents. Methanol extract inhibited both HIV-RT (91%) and HBsAg (79%) and has 11 compounds. Among the compounds, Benzene dicarboxylic acid yielded a dock score −4.85 against HIV receptor and −4.71 against HBV receptor. The obtained results indicated C. halicacabum bioactive principles potentiality as HIV and HBV co-infection controlling novel therapeutics lead compounds.

Keywords:

• anti-HIV
• molecular docking
• HIV RT
• HBsAg
• weed

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