Inhibitory Effects of Cuminum cyminum on the Mutagenicity of Direct and Indirect Mutagens in Bacterial Reverse Mutation Assay

Abstract

Antimutagenic potential of Cuminum cyminum seed oil was evaluated using modified bacterial reverse mutation assay. Salmonella typhimurium strains were used for antimutagenic evaluation with pre-, co-, and post-treatment methods with prior cytotoxicity and mutagenicity evaluation. C. cyminum oil produced cytotoxicity in S. typhimurium strains at concentrations ranging from 0.08 to 2.50 and 0.31 to 2.50 μL/plate in the absence and presence of metabolic activation, respectively. C. cyminum was non-mutagenic and exhibited a different range of antimutagenic potential in all the S. typhimurium strains at non-cytotoxic concentrations.

Keywords:

• Antimutagenicity
• Salmonella typhimurium
• Ames assay