In vitro Antischistosomal and Cytotoxic Activities of Norneolignans from Styrax pohlii A. DC.

Abstract

The schistosomicidal and cytotoxic activities of norneolignans isolated from Styrax pohlii are used to relieve fever. The norneolignans homoegonol [2] and homoegonol glucoside [4] provided the best results against S. mansoni adult worms. At 200 μM, compounds 2 and 4 killed 25% and 50% of the parasites in 120 h, while egonol [1], homoegonol gentiobioside [3], and egonol gentiobioside [5] reduced their motor activity to 12.5%, 12.5%, and 37.5% in 120 h, respectively. With respect to the cytotoxic activity, the IC₅₀ values were greater than 800 μM for 1, 5, and 3 and 192.5 and 253.1 μM for 2 and 4, respectively.

KEYWORDS:

• Styracaceae
• schistosomicidal
• egonol
• homoegonol