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Abstract
Pretreatment of Caco-2 cells with the bioaccessible fraction of bMO suppressed IL-1β-induced COX-2, IL-8 and MCP-1 and intracellular ROS content. Omission of bile extract during digestion decreased the extent of inhibitory effect of digested bMO on IL-1β activated IL-8 and MCP-1 production. Both lipophilic and hydrophilic compounds of bMO contribute to suppressive response to the pro-inflammatory insult, but only the hydrophilic compounds are responsible for its antioxidant activity. The suppressive effect of the bioaccessible fraction of bMO was partly modulated by inhibiting the phosphorylation of p-38 and IκB. These data provide supportive health promoting activity of M. oleifera pods on the gut.
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