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Abstract
Mycetia longifolia is used traditionally for the treatment of pain, inflammation, ulcers, and wounds. Phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins, glycosides, and polyphenols. The ethanol extract of the plant was investigated for its antinociceptive and anti-inflammatory activities in mice models and compared to the reference drug diclofenac sodium and control. In the acetic acid-induced writhing model, the extract showed a good antinociceptive effect characterized by the reduction in the number of writhes. The percent inhibition of writhing response by the extract was 74.56% at 500 mg.kg−1 dose. The extract caused decrease in licking time and licking frequency in mice when placed on a hot plate. The extract at doses of 250 and 500 mg.kg−1 b.w. inhibited the formation of paw edema induced by carrageenan.