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ABSTRACT
Zea mays husk extract and fractions (187–748 mg kg−1) were evaluated for antidiabetic and hypolipidemic potentials in alloxan-induced diabetic rats. Fasting blood glucose (FBG), serum insulin and lipids levels were determined. Treatment of diabetic rats with the extract/fractions caused reduction in FBG with the dichloromethane fraction having the highest activity. The extract/fractions also caused increases in serum insulin levels. The husk extract and fractions further lowered the serum lipids levels with increased HDL-cholesterol level in the treated diabetic rats. Histology of pancreas revealed absence or reductions in pathological signs in the treated diabetic rats.
Acknowledgements
The authors are grateful to Mr Nsikan Malachy of Pharmacology and Toxicology Department for providing technical assistance.