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Journal of Herbs, Spices & Medicinal Plants Volume 25, 2019 - Issue 3
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Articles

Determination of Clastogenic and Anticlastogenic Potential of Cuminum Cyminum Seed Oil Using in Vitro Micronucleus Assay in CHO-K1 Cells

Vinod Kumar GoyalDiscovery Research, Suven Life Sciences Limited, Hyderabad, IndiaCorrespondence[email protected]
,
Sthevaan VincentDiscovery Research, Suven Life Sciences Limited, Hyderabad, India
,
Santosh Kumar PandeyDiscovery Research, Suven Life Sciences Limited, Hyderabad, India
&
Ramakrishna NirogiDiscovery Research, Suven Life Sciences Limited, Hyderabad, IndiaORCID Iconhttp://orcid.org/0000-0002-2045-0784
ORCID Icon
Pages 259-270 | Received 02 Jul 2018, Published online: 06 May 2019
 
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ABSTRACT

Cumin (Cuminum cyminum) was evaluated for its clastogenic and anticlastogenic potentials using a micronucleus assay in CHO-K1 cells. No increase in micronuclei was observed at any tested concentrations compared to concurrent vehicle control, indicating that cumin seed oil did not have clastogenic potentials under test condition. To determine the anticlastogenic potential of cumin, another trial was conducted against the potential clastogenic agents; cumin did not show any anticlastogenic activity against the used clastogens.

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