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ABSTRACT
Liver toxicity was induced by anti-tubercular drugs (INH + RIF) and ethanolic extract of Galanga (Alpinia officinarum) rhizome at 200 or 400 mg kg−1 were administered orally once daily for 21 d. The hepatoprotective activity was assessed using biochemical parameters. Results demonstrated that the Galanga rhizome extracts reduced the toxicity in serum levels of hepatic enzymes. Histopathology showed that Galanga rhizome extracts attenuated the hepatocellular necrosis, regeneration, and repair of cells toward normal.
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Acknowledgments
Author thanks Prof. Syed Waseem Akhtar, Hon. Chancellor and Prof. Aqil Ahmad, Hon. Vice Chancellor for providing excellent research facility in the university. The university has provided a manuscript communication number for further communication (IU/R&D/2019-MCN000558).
Conflict of interest
The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Ethical statement
The study protocols was approved by Institutional Animal Ethical Committee (IAEC), Faculty of Pharmacy, Integral University, Lucknow (Reg no. 1213/PO/Re/S/08/CPCSEA, 5th June 2008) having approval no. IU/IAEC/18/10.