Effect of Spondias Mombin Fruit Extract on Scopolamine-induced Memory Impairment and Oxidative Stress in Mice Brain

ABSTRACT

The effect of ethanol fruit extract of Spondias mombin (FESM) against scopolamine-induced memory impairment was evaluated in mice. Swiss mice were injected with scopolamine (3 mg kg⁻¹, i.p) and treated with FESM (25, 100, and 400 mg kg⁻¹) or vitamin C (100 mg kg⁻¹) for 7 d. FESM treatment prevented scopolamine-induced memory impairment on the Y-maze and novel object recognition tests, and locomotor impairment in the open field test. Further, FESM decreased acetylcholinesterase enzyme activity in the striatum, prefrontal cortex, and hippocampus of mice brain. FESM ameliorated scopolamine-induced memory impairment via enhancement of cholinergic function and inhibition of oxidative stress in mice brains.

KEYWORDS:

• Memory
• cholinergic function
• oxidative stress

Acknowledgments

The authors acknowledged the assistance of Miss Victoria Badaki of the Department of Pharmacology and Therapeutics for picking and sorting the fruits.

Disclosure Statement

The authors declare that there are no conflicts of interest.