Pharmacological Activities of Crinum viviparum: A Laboratory-based Study

ABSTRACT

The phytochemical composition of the ethanolic extract of Crinum viviparum was determined and the anti-bacterial, anti-inflammatory, thrombolytic, and anti-diarrheal activities were investigated by applying disc diffusion, egg albumin (in vitro), clot lysis, and castor oil-induced diarrhea model in mice (in vivo), respectively. The results suggested that the crude ethanolic extract of the plant contained alkaloids, tannins, flavonoids, steroids, and terpenoids. The extract was anti-bacterial against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Salmonella enterica. The plant showed anti-inflammatory and thrombolytic activities in a concentration-dependent manner. C. viviparum extract was anti-diarrheal in Swiss albino mice at 250 and 500 mg kg⁻¹.

KEYWORDS:

• Bacterial infection
• thrombosis
• inflammation
• diarrhea

Acknowledgments

The authors thank the Department of Pharmacy of BSMRSTU, Gopalganj, Bangladesh for the laboratory facilities to conduct this project. We also owed to the Khulna University and Jahangirnagar University for kindly providing bacterial strains and mice respectively.

Conflicts Of Interest Statement

The authors declare no conflict of interest.