Immunostimulatory Effect of Moringa oleifera Extracts on Cyclophosphamide-induced Immunosuppressed Mice

ABSTRACT

In this study, the effect of Moringa oleifera extracts were investigated on an immunosuppressed model of cyclophosphamide-induced Swiss mice. M. oleifera seed and root extracts (2.0 g kg⁻¹ body wt) were administered orally for 7 consecutive days; cyclophosphamide (CP) (200 mg kg⁻¹ i.p.) was administered by IV on the 4^th day. Results indicated that the extracts of the M. oleifera seeds and roots ameliorated the immunosuppressive effects of CP on delayed type hypersensitivity (DTH) response, leukocyte counts, relative organ weight, IgM concentration, serum TNF-α assay and micro-histological images. This study demonstrated in vivo the therapeutic effect of M. oleifera on the immune response in clinical application.

KEYWORDS:

• Bioactivity
• immunostimulatory activity
• immunosuppression
• Swiss mice

Acknowledgments

This project was funded by the Research Funding Program (RFP) at Hanoi Medical University, Hanoi, Vietnam. The authors, therefore, acknowledge with thanks RFP for technical and financial support. This study was approved by the Scientific Board Committee of Hanoi Medical University (ref number: IRB00003121)

Disclosure statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Additional information

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was funded by the Research Funding Program (RFP) at Hanoi Medical University, Hanoi, Vietnam.