https://orcid.org/0000-0001-5439-8032
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ABSTRACT
The analgesic and anti-inflammatory effects of Grewia asiatica leaf solvent extracts were evaluated in animal models. The methanol and ethyl acetate fractions prepared from the leaves showed potent analgesic and anti-inflammatory effects at 400 mg kg−1 and 100 mg kg−1, respectively. Myricetin was isolated from the ethyl acetate fraction by column chromatography. Molecular docking studies with myricetin showed a desirable binding pattern of myricetin with both COX-1 and COX-2, supporting its anti-inflammatory potential. Results showed that the anti-inflammatory and analgesic effect of methanol extract of G. asiatica leaves may be due to COX-1 and COX-2 inhibition by myricetin.
Disclosure Statement
No potential conflict of interest was reported by the authors.
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Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.