Evaluation of the phytochemical Constituent, acute toxicity and antiulcer activity of Duranta erecta fruit extracts

ABSTRACT

The phytochemical constituents, acute toxicity, and antiulcer activity of Duranta erecta fruit extracts were determined in rodents. The antiulcer activity was tested utilizing a pylorus ligation. For the pylorus ligation-induced ulcer model, positive controls received ranitidine 10 mg kg⁻¹. The negative controls were given ethanol (1 mL). The hydroethanolic fruit extracts of D. erecta demonstrated no mortality or notable behavioral effects up to 5000 mg kg⁻¹. The crude ethanol fruit extract of D. erecta demonstrated antiulcer effects on pyloric ligation in rats at 500 and 1000 mg kg⁻¹ doses. The values obtained at 1000 mg kg⁻¹ dose are equivalent to those obtained with ranitidine.

KEYWORDS:

• Diarrheal
• rats
• LD₅₀
• ulcer

Acknowledgments

The authors would like to acknowledge and thank everyone involved in the success of this study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors’ contributions

JOS, OAM and JOT conducted the actual study, carried out the statistical analysis, and wrote the manuscript. JOS involved in developing the idea, designing of the study, and writing of the manuscript. OAM and JOT were involved in developing the idea and designing the study. All authors approved the submitted the final version of the manuscript.

Data availability statement

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

Ethical Approval

The study in an animal model was approved by the research and ethical committee, department of pharmacology, University of Gondar, with reference number NA/2022/129.