![Sample our Environment & Agriculture journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5934/TOC-Subject-Sample-2021-Environment-Agriculture.jpg"})
ABSTRACT
The study explored the chemical composition, antioxidant activity, and potential antihyperlipidemic effects of Allspice (Pimenta dioica) leaf essential oil. The oil yield from hydro-distillation was 1.61 ± 0.35% (v/w), with major compounds identified by GC-MS analysis as eugenol (72.06 ± 3.93%), β-pinene (9.29 ± 3.33%), chavicol (6.95 ± 0.6%), limonene (3.05 ± 0.71%), and 3-octenol (1.55 ± 1.07%). The oil’s antioxidant activity (426 ± 3.5 mg TE g−1) was attributed to polyphenols. It also reduced porcine pancreatic lipase activity, suggesting potential in managing dietary lipids. Molecular docking showed strong binding to CES1, with eugenol, limonene, β-pinene, and octenol outperforming the control (probucol). ADME-Tox predictions indicated favorable pharmacological profiles with controlled lipophilicity and toxicity.
Acknowledgments
We thank the Director, CSIR-Central Food Research Technological Research Institute, AcSIR and the Head of the Department of Plantation Products, Spices and Flavor Technology for providing constant support. The author, Ms. Shikku Premachandran M. would like to thank the University Grant Commission [521(CSIR-UGC NET JUNE 2018)], India, for the award of a research fellowship. This study was carried out under, CSIR-CFTRI MLP-270 project. The authors would also like to thank the Central Instrument Facility, CSIR-CFTRI, Mysore, for their sincere help and support. In addition, the authors would like to thank the Vellore Institute of Technology, Vellore, India, for providing the necessary research facilities and encouragement to carry out this work.
Disclosure Statement
No potential conflict of interest was reported by the author(s).
Data Availability Statement
Available from the corresponding author on reasonable request.
Human and Animal Participants
This article does not contain any studies with human or animal subjects.
List of Abbreviations
| ABTS+ | = | 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid |
| ADMET | = | Adsorption, Digestion, Metabolism, Excretion and Toxicity |
| ATR-FTIR | = | Attenuated Total Reflectance- Fourier transform infrared spectroscopy |
| BBB | = | Blood-brain barrier |
| CES 1 | = | Carboxylesterase1 |
| CK-MB | = | Creatine kinase myocardial band |
| CYP | = | Cytochrome P inhibitors |
| DMSO | = | Dimethyl sulfoxide |
| E.O | = | Essential oil |
| FRAP | = | Ferric reducing/antioxidant power |
| GC-MS | = | Gas chromatography-mass spectrometry |
| GC/FID | = | Gas chromatography with flame ionization detector |
| HTVS | = | High throughput virtual screening |
| LDL | = | Low-density lipoprotein |
| LDH-L | = | Lactate dehydrogenase |
| P – gps | = | P glycoprotein substrate |
| VLDL | = | Very low-density lipoprotein |
| TAC | = | Total Antioxidant Activity |
| TPSA | = | Topological surface area |
| QT | = | Q wave |