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Articles

Effects of subacute 3-monochloropropane-1,2-diol treatment on the kidney of male albino rats

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Pages 199-203 | Published online: 19 Nov 2018
 

ABSTRACT

3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food contaminant. Although the kidney is thought to be a target organ for 3-MCPD toxicity, nephrotoxic structural changes are relatively unstudied. We investigated the renal alterations caused by 3-MCPD in male albino rats. 3-MCPD was administered orally, at a dose of 60 mg/kg for 7 days. 3-MCPD caused significant elevation of serum creatinine and urea levels together with hydropic degeneration, necrosis and shedding of the cells of the proximal convoluted tubules, urinary casts in the distal convoluted tubules and interstitial inflammatory cell infiltration. Administration of 3-MCPD for a period as short as 7 days causes acute renal failure in male albino rats.

Acknowledgments

The authors are grateful to Mrs. Ayat Taha for for providing the 3-monochloropropane-1,2-diol.

Disclosure statement

No potential conflict of interest was reported by the authors.

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