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Biotechnic & Histochemistry Volume 96, 2021 - Issue 4
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Articles

The relation between the ghrelin receptor and FOXP3 in bladder cancer

Monireh Karimia Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranView further author information
,
Masoud Heshmatia Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranORCID Iconhttps://orcid.org/0000-0002-5486-5267View further author information
ORCID Icon,
Soheila Fattahia Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranView further author information
,
Nader Bagheria Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranORCID Iconhttps://orcid.org/0000-0001-5196-5513View further author information
ORCID Icon,
Faramarz Mohammad Alibeigib Department of Urology, Shahrekord University of Medical Sciences, Shahrekord, IranORCID Iconhttps://orcid.org/0000-0002-5391-3116View further author information
ORCID Icon,
Fatemeh Taheric Department of Pathology, Shahrekord University of Medical Sciences, Shahrekord, IranView further author information
,
Maryam Anjomshoad Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranORCID Iconhttps://orcid.org/0000-0002-8973-1736View further author information
ORCID Icon,
Mohammad-Saeid Jamie Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USAORCID Iconhttps://orcid.org/0000-0002-5055-5130View further author information
ORCID Icon &
Mahdi Ghatreh Samania Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4074-8825View further author information
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Pages 287-295 | Received 24 Dec 2019, Accepted 17 Jul 2020, Published online: 03 Aug 2020
 
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ABSTRACT

Immune responses play an important role in the fate of bladder cancer tumors. Treg cells are immunosuppressive and down-regulate the proliferation of effector T cells, which favor tumor survival. Ghrelin is a hormone that stimulates release of growth hormone and anti-inflammatory response to cancer cells. Ghrelin also is a gastrointestinal hormone that regulates immune responses via the growth hormone secretagogue receptor (GHS-R1a). The relation among ghrelin, its receptor, and Treg cells that surround bladder tumors is not clear. We found that Foxp3+ T and GHS-R1a cells are increased significantly in bladder tumor tissues. Therefore, we suggest that ghrelin may increase the number of Treg cells in the tumor and suppress activity of the immune system against bladder cancer.

Acknowledgments

The authors are grateful to the staff of Students Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by the Medical University of Shahrekord under Grant 2718.

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