The protective effects of the Lactarius deliciosus and Agrocybe cylindracea mushrooms on histopathology of carbon tetrachloride induced oxidative stress in rats

ABSTRACT

We investigated the protective effects of L. deliciosus and A. cylindracea supplementation against carbon tetrachloride (CCI₄) induced oxidative stress by measuring levels of adenosine deaminase (ADA) and myeloperoxidase (MPO), and by observing histopathological changes in liver and kidney tissues of rats. We divided 36 rats into six groups: control, CCl₄, L. deliciosus, A. cylindracea, CCl₄ + L. deliciosus, and CCl₄ + A. cylindracea. We found that administration of CCI₄, A. cylindracea, and CCl₄ + A. cylindracea increased MPO and ADA levels. We observed severe hepato-renal degenerative and necrotic lesions in the CCI₄, A. cylindracea and CCl₄ + A. cylindracea groups. Severe lesions of the liver and kidney were not observed with A. cylindracea administration. CCI₄ induced hepato-renal lesions were ameliorated by L. deliciosus extract supplementation. L. deliciosus could be an important dietary antioxidant for preventing histologic lesions in liver and kidney due to CCI₄ induced oxidative stress in rats.

KEYWORDS:

• A. cylindracea
• carbon tetrachloride
• histopathology
• L. deliciosus
• mushrooms
• oxidative stress
• rats

Acknowledgments

The authors thank all who participated in this study. Our findings are from an MSc. thesis by Songül Hasar. This paper is dedicated to the memory of Prof. Dr. Kenan Demirel.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was funded by the Van Yuzuncu Yil University Scientific Research Project Commission [Grant no: 2015-FBE-YL150].