A review of the protective effects of quercetin-rich natural compounds for treating ischemia-reperfusion injury

ABSTRACT

Ischemia-reperfusion (IR) injury causes dysfunction of tissues and organs, and oxidative stress plays an important role. During IR, reactive oxygen species (ROS) are increased. Antioxidants are used to decrease ROS associated with IR. We review the protective effects of quercetin-rich natural antioxidants against IR. We searched PubMed, ScienceDirect, Scopus and Cochrane databases using the keywords: ischemic reperfusion, quercetin, antioxidant and herbal medicine. The effects of quercetin during IR have been reported for animal models in vitro and in vivo. Quercetin-rich plants including Abelmoschus esculentus, coriander, Hypericum perforatum, onion, Psidium guajava, buckwheat and Rosa laevigata Michx have been used to reduce oxidative stress damage to various organs during IR.

KEYWORDS:

• Antioxidant
• flavonoids
• herbal medicine
• ischemia
• quercetin
• reperfusion
• review

Acknowledgments

The authors thank the School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran for their support.

Disclosure statement

No potential conflict of interest was reported by the authors.