Advanced search
Publication Cover
Biotechnic & Histochemistry Volume 98, 2023 - Issue 3
Submit an article Journal homepage
299
Views
0
CrossRef citations to date
0
Altmetric
Articles

Effects of apocynin on sciatic nerve injury in rabbits

Mehmet Akif Duraka Department of Neurosurgery, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0003-0827-2708
ORCID Icon,
Onural Ozhanb Department of Pharmacology, Medical School, Inonu University, Malatya, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9018-7849
ORCID Icon,
Bora Tetika Department of Neurosurgery, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0001-7696-7785
ORCID Icon,
Azibe Yildizc Department of Histology and Embryology, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0001-5686-7867
ORCID Icon,
Zeynep Aksungurd Department of Biochemistry, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0002-9002-6604
ORCID Icon,
Nigar Vardic Department of Histology and Embryology, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0003-0576-1696
ORCID Icon,
Yusuf Turkozd Department of Biochemistry, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0001-5401-0720
ORCID Icon,
Muharrem Ucare Department of Anesthesiology, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0002-1232-9829
ORCID Icon &
Hakan Parlakpinarb Department of Pharmacology, Medical School, Inonu University, Malatya, TurkeyORCID Iconhttps://orcid.org/0000-0002-4083-3897
ORCID Icon show all
Pages 172-178 | Published online: 28 Nov 2022
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

ABSTRACT

We investigated the effects of apocynin (APO) on experimental sciatic nerve compression injury in rabbits. We used 21 male rabbits divided randomly into three groups of seven. The control group was subjected to sciatic nerve compression with no further intervention. The APO treated group was subjected to compression injury and 20 mg/kg APO was administered daily for 21 days by intraperitoneal injection beginning the day after the injury. The sham group was treated with APO without injury. The control group exhibited shrinkage of axons, disruption of myelin sheaths and loss of nerve fibers. The damage for the control group was significantly greater than for the sham group. The severity of histopathology was decreased in the APO treated group compared to the control group, as was the oxidative stress index. Our findings suggest that APO treatment may contribute to healing of sciatic nerve damage.

Disclosure statement

The authors declare no conflict of interest.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 203.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.